Variant Summary
- Also known as
- VAL600LYS,RS121913227
- HGVS
- ENST00000288602.6:c.1798_1799delinsAA,NC_000007.13:g.140453136_140453137delinsTT,NM_004333.4:c.1798_1799delGTinsAA,NP_004324.2:p.Val600Lys
- Variant Type(s)
- missense_variant
- Evidence Items
- 9
Evidence Level Distribution
Level B: 8Level C: 1
Evidence Items
Showing CIViC evidence rows where gene = BRAF and variant = V600K.
| Level | Type | Direction | Significance | Disease | Drugs | Rating |
|---|---|---|---|---|---|---|
| B | Predictive | Supports | Sensitivity/Response | Melanoma | Vemurafenib | 4 |
| B | Predictive | Supports | Sensitivity/Response | Melanoma | Dabrafenib,Trametinib | 4 |
| B | Predictive | Supports | Sensitivity/Response | Melanoma | Dabrafenib,Trametinib | 4 |
| C | Predictive | Supports | Sensitivity/Response | Melanoma | Vemurafenib | 3 |
| B | Predictive | Supports | Sensitivity/Response | Melanoma | Vemurafenib | 3 |
| B | Predictive | Supports | Sensitivity/Response | Skin Melanoma | Dabrafenib,Trametinib | 3 |
| B | Predictive | Supports | Sensitivity/Response | Melanoma | Trametinib,Dabrafenib | 3 |
| B | Predictive | Supports | Sensitivity/Response | Melanoma | Trametinib | 2 |
| B | Predictive | Supports | Sensitivity/Response | Melanoma | Dabrafenib | 0 |