CIViC Compass
Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.
CIViC Variants/Mutation

Mutation

CIViC ID: 570 · Gene: IDH2

Variant Summary

HGVS
—
Variant Type(s)
protein_altering_variant
Evidence Items
6

Evidence Level Distribution

Level A: 1Level B: 3Level C: 1Level D: 1

Evidence Items

Showing CIViC evidence rows where gene = IDH2 and variant = Mutation.

LevelTypeDirectionSignificanceDiseaseDrugsRating
DPredictiveSupportsSensitivity/ResponseAcute Myeloid LeukemiaEnasidenib4
APredictiveSupportsSensitivity/ResponseAcute Myeloid LeukemiaEnasidenib4
BPrognosticSupportsBetter OutcomeChondrosarcoma4
BPrognosticSupportsBetter OutcomeBrain Glioma3
BPrognosticDoes Not SupportAcute Myeloid Leukemia3
CPredictiveSupportsSensitivity/ResponseAcute Myeloid LeukemiaVenetoclax3