Variant Summary
- Also known as
- LYS483MET
- HGVS
- NC_000007.13:g.140477859_140477860delinsCA,ENST00000288602.6:c.1448_1449delinsTG
- Variant Type(s)
- missense_variant,loss_of_function_variant
- Evidence Items
- 1
Evidence Level Distribution
Level E: 1
Evidence Items
Showing CIViC evidence rows where gene = BRAF and variant = K483M.
| Level | Type | Direction | Significance | Disease | Drugs | Rating |
|---|---|---|---|---|---|---|
| E | Predictive | Supports | Sensitivity/Response | Skin Melanoma | Sorafenib,Mitogen-Activated Protein Kinase Kinase Inhibitor | 3 |