Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.

CIViC Variants/Mutation

Mutation

CIViC ID: 587 · Gene: NF1

Variant Summary

HGVS: —
Variant Type(s): loss_of_function_variant,protein_altering_variant
Evidence Items: 7

Evidence Level Distribution

Level A: 2Level B: 1Level C: 1Level D: 3

Evidence Items

Showing CIViC evidence rows where gene = NF1 and variant = Mutation.

Level	Type	Direction	Significance	Disease	Drugs	Rating
A	Predictive	Supports	Sensitivity/Response	Plexiform Neurofibroma	Selumetinib	4
C	Predictive	Supports	Resistance	Skin Melanoma	Vemurafenib	4
D	Predictive	Supports	Sensitivity/Response	Skin Melanoma	Sirolimus,Mirdametinib	3
A	Predictive	Supports	Sensitivity/Response	Plexiform Neurofibroma	Selumetinib	3
B	Predictive	Supports	Sensitivity/Response	Childhood Low-grade Glioma	Selumetinib	3
D	Predictive	Supports	Resistance	Skin Melanoma	Vemurafenib	2
D	Predictive	Supports	Sensitivity/Response	Skin Melanoma	VTX-11e,AZ628	2