CIViC Compass
Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.
CIViC Variants/R132C

R132C

CIViC ID: 59 · Gene: IDH1

Variant Summary

Also known as
RS121913499,ARG132CYS
HGVS
NM_005896.3:c.394C>T,NP_005887.2:p.Arg132Cys,NC_000002.11:g.209113113G>A,ENST00000415913.1:c.394C>T
Variant Type(s)
missense_variant
Evidence Items
8

Evidence Level Distribution

Level B: 4Level D: 4

Evidence Items

Showing CIViC evidence rows where gene = IDH1 and variant = R132C.

LevelTypeDirectionSignificanceDiseaseDrugsRating
DPredictiveSupportsSensitivity/ResponseCancerOlaparib3
BDiagnosticSupportsPositiveAcute Myeloid Leukemia3
DPredictiveSupportsSensitivity/ResponseAcute Myeloid LeukemiaBPTES3
DPredictiveSupportsSensitivity/ResponseAcute Myeloid LeukemiaGSK3213
BPredictiveSupportsSensitivity/ResponseBrain GliomaTemozolomide2
DPredictiveSupportsSensitivity/ResponseHigh Grade GliomaAGI-51982
BPredictiveSupportsSensitivity/ResponseAcute Myeloid LeukemiaIvosidenib2
BPrognosticDoes Not SupportAcute Myeloid Leukemia2