CIViC Compass
Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.
CIViC Variants/Loss-of-function

Loss-of-function

CIViC ID: 601 · Gene: NOTCH1

Variant Summary

HGVS
—
Variant Type(s)
loss_of_function_variant
Evidence Items
1

Evidence Level Distribution

Level D: 1

Evidence Items

Showing CIViC evidence rows where gene = NOTCH1 and variant = Loss-of-function.

LevelTypeDirectionSignificanceDiseaseDrugsRating
DPredictiveSupportsSensitivity/ResponseHead And Neck Squamous Cell CarcinomaPorcupine Inhibitor WNT9742