Variant Summary
- Also known as
- ASP594GLY,RS121913338
- HGVS
- NM_004333.4:c.1781A>G,NP_004324.2:p.Asp594Gly,NC_000007.13:g.140453154T>C,ENST00000288602.6:c.1781A>G
- Variant Type(s)
- missense_variant
- Evidence Items
- 8
Evidence Level Distribution
Level B: 2Level C: 3Level D: 3
Evidence Items
Showing CIViC evidence rows where gene = BRAF and variant = D594G.
| Level | Type | Direction | Significance | Disease | Drugs | Rating |
|---|---|---|---|---|---|---|
| C | Predictive | Does Not Support | Resistance | Colorectal Cancer | Cetuximab,Irinotecan | 3 |
| C | Predictive | Supports | Resistance | Colorectal Cancer | Cetuximab,Irinotecan | 3 |
| D | Predictive | Supports | Sensitivity/Response | Skin Melanoma | Sorafenib | 3 |
| D | Predictive | Supports | Resistance | Skin Melanoma | U0126 | 3 |
| D | Predictive | Does Not Support | Sensitivity/Response | Cancer | Vemurafenib | 3 |
| B | Prognostic | Supports | Poor Outcome | Colorectal Cancer | 2 | |
| B | Prognostic | Supports | Poor Outcome | Colorectal Cancer | 1 | |
| C | Predictive | Does Not Support | Resistance | Colorectal Cancer | Cetuximab,Panitumumab | 1 |