CIViC Compass
Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.
CIViC Variants/S249C

S249C

CIViC ID: 628 · Gene: FGFR3

Variant Summary

Also known as
SER249CYS,RS121913483
HGVS
NC_000004.11:g.1803568C>G,NM_000142.4:c.746C>G,NP_000133.1:p.Ser249Cys,ENST00000340107.4c.746C>G
Variant Type(s)
missense_variant
Evidence Items
7

Evidence Level Distribution

Level C: 1Level D: 6

Evidence Items

Showing CIViC evidence rows where gene = FGFR3 and variant = S249C.

LevelTypeDirectionSignificanceDiseaseDrugsRating
DPredictiveSupportsSensitivity/ResponseCancerInfigratinib,PD1730744
DOncogenicSupportsOncogenicityBladder Urothelial Carcinoma4
DOncogenicSupportsOncogenicityLung Squamous Cell Carcinoma3
DPredictiveSupportsResistanceTransitional Cell CarcinomaCisplatin3
DFunctionalSupportsGain of Function3
DOncogenicSupportsOncogenicityTransitional Cell Carcinoma3
CPredictiveSupportsSensitivity/ResponseTransitional Cell CarcinomaPazopanib2