CIViC Compass
Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.
CIViC Variants/V617F

V617F

CIViC ID: 64 · Gene: JAK2

Variant Summary

Also known as
VAL617PHE,RS77375493
HGVS
NC_000009.11:g.5073770G>T,NM_004972.3:c.1849G>T,NP_004963.1:p.Val617Phe,ENST00000381652.3:c.1849G>T
Variant Type(s)
missense_variant,gain_of_function_variant
Evidence Items
6

Evidence Level Distribution

Level B: 5Level D: 1

Evidence Items

Showing CIViC evidence rows where gene = JAK2 and variant = V617F.

LevelTypeDirectionSignificanceDiseaseDrugsRating
BDiagnosticSupportsNegativeLymphoid Leukemia4
BPredictiveSupportsSensitivity/ResponsePolycythemia VeraPeginterferon Alfa-2b4
BDiagnosticSupportsPositiveChronic Myeloid Leukemia4
BDiagnosticSupportsPositiveChronic Myeloid Leukemia4
BDiagnosticSupportsPositiveBone Marrow Cancer4
DPredictiveSupportsSensitivity/ResponsePolycythemia VeraFedratinib3