Variant Summary
- Also known as
- D1246N,ASP1246ASN,ASP1228ASN
- HGVS
- NC_000007.13:g.116423407G>A,NC_000007.14:g.116783353G>A,ENST00000397752.8:c.3682G>A,ENSP00000380860.3:p.Asp1228Asn,ENST00000397752.7:c.3682G>A,ENSP00000380860.3:p.Asp1228Asn,NM_000245.4:c.3682G>A,NP_000236.2:p.Asp1228Asn,NM_000245.3:c.3682G>A,NP_000236.2:p.Asp1228Asn
- Variant Type(s)
- missense_variant
- Evidence Items
- 1
Evidence Level Distribution
Level C: 1
Evidence Items
Showing CIViC evidence rows where gene = MET and variant = D1228N.
| Level | Type | Direction | Significance | Disease | Drugs | Rating |
|---|---|---|---|---|---|---|
| C | Predictive | Supports | Resistance | Lung Non-small Cell Carcinoma | Crizotinib | 2 |