CIViC Compass
Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.
CIViC Variants/D816V

D816V

CIViC ID: 65 · Gene: KIT

Variant Summary

Also known as
ASP816VAL,RS121913507
HGVS
NM_000222.2:c.2447A>T,NP_000213.1:p.Asp816Val,ENST00000288135.5:c.2447A>T,NC_000004.11:g.55599321A>T
Variant Type(s)
missense_variant
Evidence Items
5

Evidence Level Distribution

Level B: 3Level C: 1Level D: 1

Evidence Items

Showing CIViC evidence rows where gene = KIT and variant = D816V.

LevelTypeDirectionSignificanceDiseaseDrugsRating
BPredictiveSupportsSensitivity/ResponseSystemic MastocytosisMidostaurin4
BPrognosticSupportsPoor OutcomeSystemic Mastocytosis4
BPrognosticSupportsPoor OutcomeAcute Myeloid Leukemia4
DPredictiveSupportsResistanceCancerImatinib2
CPredictiveSupportsResistanceCancerImatinib,Dasatinib2