Variant Summary
- Also known as
- LEU505HIS
- HGVS
- ENST00000288602.6:c.1514T>A,NC_000007.13:g.140477794A>T,NM_004333.4:c.1514T>A,NP_004324.2:p.Leu505His
- Variant Type(s)
- missense_variant
- Evidence Items
- 2
Evidence Level Distribution
Level B: 1Level D: 1
Evidence Items
Showing CIViC evidence rows where gene = BRAF and variant = L505H.
| Level | Type | Direction | Significance | Disease | Drugs | Rating |
|---|---|---|---|---|---|---|
| D | Predictive | Supports | Resistance | Melanoma | Vemurafenib | 4 |
| B | Predictive | Supports | Resistance | Melanoma | Vemurafenib | 3 |