Variant Summary
- HGVS
- —
- Variant Type(s)
- coding_sequence_variant
- Evidence Items
- 13
Evidence Level Distribution
Level A: 1Level B: 11Level C: 1
Evidence Items
Showing CIViC evidence rows where gene = KIT and variant = Exon 11 Mutation.
| Level | Type | Direction | Significance | Disease | Drugs | Rating |
|---|---|---|---|---|---|---|
| B | Predictive | Supports | Sensitivity/Response | Gastrointestinal Stromal Tumor | Imatinib | 4 |
| A | Predictive | Supports | Sensitivity/Response | Gastrointestinal Stromal Tumor | Imatinib | 4 |
| C | Predictive | Supports | Sensitivity/Response | Melanoma | Sunitinib | 3 |
| B | Prognostic | Does Not Support | Gastrointestinal Stromal Tumor | 3 | ||
| B | Prognostic | Supports | Poor Outcome | Gastrointestinal Stromal Tumor | 3 | |
| B | Predictive | Supports | Resistance | Gastrointestinal Stromal Tumor | Sunitinib | 3 |
| B | Prognostic | Does Not Support | Gastrointestinal Stromal Tumor | 3 | ||
| B | Predictive | Supports | Sensitivity/Response | Melanoma | Imatinib | 3 |
| B | Predictive | Supports | Sensitivity/Response | Gastrointestinal Stromal Tumor | Regorafenib Anhydrous | 3 |
| B | Diagnostic | Supports | Positive | Gastrointestinal Stromal Tumor | 2 | |
| B | Prognostic | Does Not Support | Lung Cancer | 2 | ||
| B | Predictive | Supports | Sensitivity/Response | Gastrointestinal Stromal Tumor | Regorafenib Anhydrous | 2 |
| B | Predictive | Supports | Sensitivity/Response | Gastrointestinal Stromal Tumor | Regorafenib Anhydrous | 2 |