CIViC Compass
Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.
CIViC Variants/Mutation

Mutation

CIViC ID: 666 · Gene: ERBB2

Variant Summary

HGVS
—
Variant Type(s)
missense_variant
Evidence Items
5

Evidence Level Distribution

Level A: 2Level B: 2Level C: 1

Evidence Items

Showing CIViC evidence rows where gene = ERBB2 and variant = Mutation.

LevelTypeDirectionSignificanceDiseaseDrugsRating
APredictiveSupportsSensitivity/ResponseLung Non-small Cell CarcinomaTrastuzumab Deruxtecan4
APredictiveSupportsSensitivity/ResponseLung Non-small Cell CarcinomaZongertinib4
BPredictiveSupportsSensitivity/ResponseBreast CancerNeratinib4
CPredictiveSupportsSensitivity/ResponseBladder CarcinomaPlatinum Compound3
BPredictiveSupportsSensitivity/ResponseLung Non-small Cell CarcinomaPertuzumab,Trastuzumab2