CIViC Compass
Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.
CIViC Variants/L576P

L576P

CIViC ID: 72 · Gene: KIT

Variant Summary

Also known as
RS121913513,LEU576PRO
HGVS
NM_000222.2:c.1727T>C,NP_000213.1:p.Leu576Pro,ENST00000288135.5:c.1727T>C,NC_000004.11:g.55593661T>C
Variant Type(s)
missense_variant
Evidence Items
5

Evidence Level Distribution

Level C: 1Level D: 4

Evidence Items

Showing CIViC evidence rows where gene = KIT and variant = L576P.

LevelTypeDirectionSignificanceDiseaseDrugsRating
DPredictiveSupportsSensitivity/ResponseLung Non-small Cell CarcinomaDasatinib,Nilotinib,Imatinib3
DPredictiveSupportsResistanceMelanomaImatinib,Nilotinib,Sorafenib3
DPredictiveSupportsSensitivity/ResponseMelanomaDasatinib3
CPredictiveSupportsResistanceGastrointestinal Stromal TumorSunitinib2
DPredictiveSupportsSensitivity/ResponseCancerDasatinib,Imatinib2