CIViC Compass
Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.
CIViC Variants/Exon 20 Insertion

Exon 20 Insertion

CIViC ID: 726 · Gene: EGFR

Variant Summary

HGVS
—
Variant Type(s)
inframe_insertion
Evidence Items
7

Evidence Level Distribution

Level A: 4Level B: 2Level C: 1

Evidence Items

Showing CIViC evidence rows where gene = EGFR and variant = Exon 20 Insertion.

LevelTypeDirectionSignificanceDiseaseDrugsRating
APredictiveSupportsSensitivity/ResponseLung Non-small Cell CarcinomaAmivantamab4
APredictiveSupportsSensitivity/ResponseLung Non-small Cell CarcinomaMobocertinib4
APredictiveSupportsSensitivity/ResponseLung Non-small Cell CarcinomaAmivantamab,Chemotherapy4
APredictiveSupportsSensitivity/ResponseLung Non-small Cell CarcinomaSunvozertinib4
BPredictiveSupportsResistanceLung AdenocarcinomaAfatinib3
BPredictiveSupportsSensitivity/ResponseLung Non-small Cell CarcinomaOsimertinib2
CPredictiveSupportsResistanceLung AdenocarcinomaErlotinib0