Variant Summary
- Also known as
- RS121913523,VAL654ALA
- HGVS
- NC_000004.11:g.55594258T>C,NM_000222.2:c.1961T>C,NP_000213.1:p.Val654Ala,ENST00000288135.5:c.1961T>C
- Variant Type(s)
- missense_variant
- Evidence Items
- 2
Evidence Level Distribution
Level B: 1Level D: 1
Evidence Items
Showing CIViC evidence rows where gene = KIT and variant = V654A.
| Level | Type | Direction | Significance | Disease | Drugs | Rating |
|---|---|---|---|---|---|---|
| D | Predictive | Supports | Resistance | Gastrointestinal Stromal Tumor | Imatinib | 3 |
| B | Predictive | Supports | Sensitivity/Response | Gastrointestinal Stromal Tumor | Sunitinib | 3 |