Variant Summary
- Also known as
- ASP1228VAL,D1246V,ASP1246VAL
- HGVS
- ENST00000318493.11:c.3737A>T,ENSP00000317272.6:p.Asp1246Val,NM_001127500.3:c.3737A>T,NP_001120972.1:p.Asp1246Val
- Variant Type(s)
- missense_variant
- Evidence Items
- 2
Evidence Level Distribution
Level C: 2
Evidence Items
Showing CIViC evidence rows where gene = MET and variant = D1228V.
| Level | Type | Direction | Significance | Disease | Drugs | Rating |
|---|---|---|---|---|---|---|
| C | Predictive | Supports | Sensitivity/Response | Lung Non-small Cell Carcinoma | Cabozantinib | 4 |
| C | Predictive | Supports | Resistance | Lung Non-small Cell Carcinoma | Savolitinib | 4 |