Variant Summary
- Also known as
- EXON 12 MUTATION
- HGVS
- —
- Variant Type(s)
- exon_variant
- Evidence Items
- 29
Evidence Level Distribution
Level A: 1Level B: 25Level D: 1Level E: 2
Evidence Items
Showing CIViC evidence rows where gene = NPM1 and variant = EXON 11 MUTATION.
| Level | Type | Direction | Significance | Disease | Drugs | Rating |
|---|---|---|---|---|---|---|
| A | Diagnostic | Supports | Positive | Acute Myeloid Leukemia | 5 | |
| B | Prognostic | Supports | Better Outcome | Acute Myeloid Leukemia | 5 | |
| B | Prognostic | Supports | Poor Outcome | Acute Myeloid Leukemia | 4 | |
| B | Diagnostic | Supports | Negative | Acute Myeloid Leukemia | 4 | |
| B | Diagnostic | Supports | Positive | Acute Myeloid Leukemia | 4 | |
| B | Prognostic | Supports | Better Outcome | Acute Myeloid Leukemia | 4 | |
| B | Prognostic | Supports | Better Outcome | Acute Myeloid Leukemia | 4 | |
| B | Prognostic | Supports | Better Outcome | Acute Myeloid Leukemia | 4 | |
| B | Diagnostic | Supports | Positive | Acute Myeloid Leukemia | 3 | |
| B | Diagnostic | Supports | Positive | Acute Myeloid Leukemia | 3 | |
| B | Prognostic | Does Not Support | Better Outcome | Acute Myeloid Leukemia | 3 | |
| B | Predictive | Does Not Support | Sensitivity/Response | Acute Myeloid Leukemia | Tretinoin | 3 |
| D | Predictive | Supports | Sensitivity/Response | Acute Myeloid Leukemia | Tretinoin,NSC348884 | 3 |
| B | Prognostic | Supports | Better Outcome | Acute Myeloid Leukemia | 3 | |
| B | Prognostic | Supports | Better Outcome | Acute Myeloid Leukemia | 3 | |
| B | Prognostic | Supports | Better Outcome | Acute Myeloid Leukemia | 3 | |
| B | Prognostic | Supports | Better Outcome | Acute Myeloid Leukemia | 3 | |
| B | Prognostic | Supports | Better Outcome | Acute Myeloid Leukemia | 3 | |
| B | Prognostic | Supports | Better Outcome | Acute Myeloid Leukemia | 3 | |
| B | Prognostic | Supports | Better Outcome | Acute Myeloid Leukemia | 3 | |
| B | Prognostic | Supports | Poor Outcome | Acute Myeloid Leukemia | 3 | |
| B | Diagnostic | Supports | Positive | Acute Myeloid Leukemia | 2 | |
| B | Predictive | Supports | Sensitivity/Response | Acute Myeloid Leukemia | Tretinoin | 2 |
| B | Predictive | Supports | Sensitivity/Response | Acute Myeloid Leukemia | Daunorubicin | 2 |
| B | Predictive | Supports | Sensitivity/Response | Acute Myeloid Leukemia | Valproic Acid | 2 |
| E | Predictive | Supports | Sensitivity/Response | Acute Myeloid Leukemia | Anti-CD123,Anti-CD33 | 2 |
| E | Predictive | Supports | Sensitivity/Response | Acute Myeloid Leukemia | Anti-CD33 | 2 |
| B | Prognostic | Supports | Better Outcome | Acute Myeloid Leukemia | 2 | |
| B | Prognostic | Supports | Poor Outcome | Acute Myeloid Leukemia | 2 |