Variant Summary
- Also known as
- NPM1-A,RS587776806,TRP288FS
- HGVS
- NM_002520.6:c.860_863dupTCTG,NC_000005.9:g.170837544_170837547dupTCTG,NP_002511.1:p.Trp288Cysfs,ENST00000517671.1:c.860_863dupTCTG
- Variant Type(s)
- frameshift_elongation
- Evidence Items
- 3
Evidence Level Distribution
Level B: 1Level D: 1Level E: 1
Evidence Items
Showing CIViC evidence rows where gene = NPM1 and variant = W288FS.
| Level | Type | Direction | Significance | Disease | Drugs | Rating |
|---|---|---|---|---|---|---|
| D | Predictive | Supports | Sensitivity/Response | Acute Myeloid Leukemia | NSC348884 | 3 |
| E | Predictive | Supports | Sensitivity/Response | Acute Myeloid Leukemia | Daunorubicin,Cytarabine,Etoposide | 3 |
| B | Prognostic | Does Not Support | Better Outcome | Acute Myeloid Leukemia | 2 |