CIViC Compass
Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.
CIViC Variants/c.393T>C

c.393T>C

CIViC ID: 877 · Gene: GNAS

Variant Summary

Also known as
I131=,RS7121,L131=
HGVS
NC_000020.11:g.58903752C>T,NC_000020.10:g.57478807C>T,NM_000516.4:c.393C>T,NP_000507.1:p.Ile131=
Variant Type(s)
synonymous_variant
Evidence Items
9

Evidence Level Distribution

Level B: 9

Evidence Items

Showing CIViC evidence rows where gene = GNAS and variant = c.393T>C.

LevelTypeDirectionSignificanceDiseaseDrugsRating
BPrognosticSupportsPoor OutcomeBreast Carcinoma4
BPrognosticSupportsPoor OutcomeBladder Urothelial Carcinoma4
BPrognosticSupportsBetter OutcomeColorectal Cancer4
BPredictiveSupportsResistanceEsophageal CancerCisplatin,Fluorouracil4
BPrognosticSupportsBetter OutcomeClear Cell Renal Cell Carcinoma4
BPrognosticSupportsBetter OutcomeChronic Lymphocytic Leukemia4
BPrognosticSupportsPoor OutcomeMelanoma4
BPrognosticSupportsPoor OutcomeIntrahepatic Cholangiocarcinoma3
BPredictiveSupportsResistanceLung Non-small Cell CarcinomaGefitinib,Erlotinib2