Variant Summary
- Also known as
- RS28934575
- HGVS
- NC_000017.10:g.7577548C>T,NM_000546.5:c.733G>A,NP_000537.3:p.Gly245Ser,ENST00000269305.4:c.733G>A
- Variant Type(s)
- missense_variant
- Evidence Items
- 4
Evidence Level Distribution
Level D: 4
Evidence Items
Showing CIViC evidence rows where gene = TP53 and variant = G245S.
| Level | Type | Direction | Significance | Disease | Drugs | Rating |
|---|---|---|---|---|---|---|
| D | Predictive | Supports | Resistance | Cancer | MDM2 Inhibitor AMGMDS3 | 4 |
| D | Functional | Supports | Dominant Negative | 3 | ||
| D | Functional | Supports | Dominant Negative | 3 | ||
| D | Functional | Supports | Dominant Negative | 3 |