Variant Summary
- Also known as
- RS121913527,ALA146THR
- HGVS
- NM_004985.4:c.436G>A,NP_004976.2:p.Ala146Thr,NC_000012.11:g.25378562C>T,ENST00000256078.4:c.436G>A
- Variant Type(s)
- missense_variant
- Evidence Items
- 3
Evidence Level Distribution
Level B: 1Level D: 2
Evidence Items
Showing CIViC evidence rows where gene = KRAS and variant = A146T.
| Level | Type | Direction | Significance | Disease | Drugs | Rating |
|---|---|---|---|---|---|---|
| D | Predictive | Supports | Sensitivity/Response | Colorectal Cancer | Selumetinib,Dactolisib | 3 |
| D | Predictive | Supports | Resistance | Colorectal Cancer | Cetuximab | 3 |
| B | Predictive | Supports | Resistance | Colorectal Cancer | Cetuximab,FOLFOX-4 Regimen | 3 |