CIViC Compass
Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.
CIViC Variants/G12S

G12S

CIViC ID: 913 · Gene: KRAS

Variant Summary

Also known as
RS121913530,GLY12SER
HGVS
NM_004985.4:c.34G>A,NP_004976.2:p.Gly12Ser,NC_000012.11:g.25398285C>T,ENST00000256078.4:c.34G>A
Variant Type(s)
missense_variant
Evidence Items
8

Evidence Level Distribution

Level B: 2Level C: 2Level D: 4

Evidence Items

Showing CIViC evidence rows where gene = KRAS and variant = G12S.

LevelTypeDirectionSignificanceDiseaseDrugsRating
BPredictiveSupportsResistanceColorectal CancerCetuximab3
BPredictiveSupportsResistanceLung CancerGefitinib2
DPredictiveSupportsResistanceMultiple MyelomaMelphalan2
DPredictiveSupportsResistanceMultiple MyelomaMelphalan2
DPredictiveSupportsResistanceMultiple MyelomaMelphalan2
DPredictiveSupportsResistanceColorectal CancerRegorafenib Anhydrous2
CPredictiveSupportsResistanceColorectal CancerPanitumumab,Cetuximab2
CPredictiveSupportsResistanceColorectal CancerPanitumumab0