Variant Summary
- Also known as
- RS121912666,TYR220CYS
- HGVS
- NM_000546.5:c.659A>G,NP_000537.3:p.Tyr220Cys,NC_000017.10:g.7578190T>C,ENST00000269305.4:c.659A>G
- Variant Type(s)
- missense_variant
- Evidence Items
- 4
Evidence Level Distribution
Level C: 1Level D: 3
Evidence Items
Showing CIViC evidence rows where gene = TP53 and variant = Y220C.
| Level | Type | Direction | Significance | Disease | Drugs | Rating |
|---|---|---|---|---|---|---|
| D | Predictive | Supports | Resistance | Cancer | MDM2 Inhibitor AMGMDS3 | 4 |
| D | Functional | Does Not Support | Neomorphic | 4 | ||
| C | Predictive | Supports | Sensitivity/Response | Stomach Carcinoma | Cisplatin,Mitomycin,Etoposide | 3 |
| D | Functional | Does Not Support | Loss of Function | 3 |