Variant Summary
- Also known as
- RS121913287,ARG88GLN
- HGVS
- NC_000003.12:g.179199088G>A,NC_000003.11:g.178916876G>A,NM_006218.4:c.263G>A,NP_006209.2:p.Arg88Gln
- Variant Type(s)
- missense_variant
- Evidence Items
- 2
Evidence Level Distribution
Level A: 1Level C: 1
Evidence Items
Showing CIViC evidence rows where gene = PIK3CA and variant = R88Q.
| Level | Type | Direction | Significance | Disease | Drugs | Rating |
|---|---|---|---|---|---|---|
| C | Predictive | Does Not Support | Resistance | Colorectal Cancer | Irinotecan,Cetuximab | 3 |
| A | Predictive | Supports | Sensitivity/Response | Her2-receptor Negative Breast Cancer | Fulvestrant,Capivasertib | 2 |