CIViC Compass
Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.
CIViC Variants/C420R

C420R

CIViC ID: 931 · Gene: PIK3CA

Variant Summary

Also known as
RS121913272,CYS420ARG
HGVS
NM_006218.3:c.1258T>C,NP_006209.2:p.Cys420Arg,NC_000003.11:g.178927980T>C,ENST00000263967.3:c.1258T>C
Variant Type(s)
missense_variant
Evidence Items
5

Evidence Level Distribution

Level A: 1Level C: 1Level D: 3

Evidence Items

Showing CIViC evidence rows where gene = PIK3CA and variant = C420R.

LevelTypeDirectionSignificanceDiseaseDrugsRating
APredictiveSupportsSensitivity/ResponseBreast CancerFulvestrant,Alpelisib4
CPredictiveDoes Not SupportResistanceColorectal CancerCetuximab3
DPredictiveSupportsSensitivity/ResponseHer2-receptor Positive Breast CancerPictilisib3
DPredictiveDoes Not SupportResistanceHer2-receptor Positive Breast CancerTrastuzumab Emtansine3
DPredictiveSupportsResistanceHer2-receptor Positive Breast CancerTrastuzumab2