CIViC Compass
Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.
CIViC Variants/K642E

K642E

CIViC ID: 978 · Gene: KIT

Variant Summary

Also known as
RS121913512,LYS642GLU
HGVS
NM_000222.2:c.1924A>G,NP_000213.1:p.Lys642Glu,NC_000004.11:g.55594221A>G,ENST00000288135.5:c.1924A>G
Variant Type(s)
missense_variant
Evidence Items
4

Evidence Level Distribution

Level C: 2Level D: 2

Evidence Items

Showing CIViC evidence rows where gene = KIT and variant = K642E.

LevelTypeDirectionSignificanceDiseaseDrugsRating
DPredictiveSupportsSensitivity/ResponseGastrointestinal Stromal TumorPonatinib,Sunitinib3
DPredictiveDoes Not SupportResistanceCancerImatinib2
CPredictiveSupportsSensitivity/ResponseMucosal MelanomaImatinib2
CPredictiveSupportsSensitivity/ResponseMelanomaDasatinib0