Variant Summary
- Also known as
- ASP820TYR,RS1057519710
- HGVS
- NM_000222.2:c.2458G>T,NP_000213.1:p.Asp820Tyr,NC_000004.11:g.55599332G>T,ENST00000288135.5:c.2458G>T
- Variant Type(s)
- missense_variant
- Evidence Items
- 3
Evidence Level Distribution
Level C: 2Level D: 1
Evidence Items
Showing CIViC evidence rows where gene = KIT and variant = D820Y.
| Level | Type | Direction | Significance | Disease | Drugs | Rating |
|---|---|---|---|---|---|---|
| C | Predictive | Supports | Resistance | Melanoma | Imatinib | 3 |
| D | Predictive | Supports | Sensitivity/Response | Melanoma | Sunitinib | 2 |
| C | Predictive | Supports | Sensitivity/Response | Gastrointestinal Stromal Tumor | Regorafenib Anhydrous | 2 |