CIViC Compass
Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.
CIViC Variants/D842V

D842V

CIViC ID: 99 · Gene: PDGFRA

Variant Summary

Also known as
ASP842VAL,RS121908585
HGVS
NM_006206.4:c.2525A>T,NP_006197.1:p.Asp842Val,ENST00000257290.5:c.2525A>T,NC_000004.11:g.55152093A>T
Variant Type(s)
missense_variant
Evidence Items
11

Evidence Level Distribution

Level B: 4Level C: 2Level D: 5

Evidence Items

Showing CIViC evidence rows where gene = PDGFRA and variant = D842V.

LevelTypeDirectionSignificanceDiseaseDrugsRating
BPredictiveSupportsResistanceGastrointestinal Stromal TumorImatinib4
BPredictiveSupportsResistanceGastrointestinal Stromal TumorImatinib4
DPredictiveSupportsSensitivity/ResponseGastrointestinal Stromal TumorCrenolanib4
BPredictiveSupportsResistanceGastrointestinal Stromal TumorImatinib4
BDiagnosticSupportsNegativeGastrointestinal Stromal Tumor3
CPredictiveSupportsResistanceGastrointestinal Stromal TumorSunitinib3
DPredictiveSupportsResistanceGastrointestinal Stromal TumorImatinib3
DPredictiveSupportsResistanceCancerImatinib2
CPredictiveSupportsResistanceGastrointestinal Stromal TumorImatinib2
DPredictiveSupportsResistanceCancerSunitinib2
DPredictiveSupportsResistanceCancerImatinib Mesylate2