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AKT1 E17K mutation (HR+/HER2- breast)

Gene: AKT1 · Type: mutation

Indications: Breast cancer

SensitivityResistanceCIViC Context

Linked CIViC Profile: AKT1 E17K

Evidence Level Distribution

Level B: 1Level C: 1Level D: 3
LevelTypeDirectionSignificanceDiseaseDrugsRating
BPredictiveSupportsSensitivity/ResponseCancerCapivasertib4
DPredictiveDoes Not SupportSensitivity/ResponseBreast CancerAkt Inhibitor MK22063
CPredictiveSupportsSensitivity/ResponseBreast CancerCapivasertib3
DPredictiveSupportsSensitivity/ResponseMelanomaUprosertib2
DPredictiveSupportsResistanceMelanomaVemurafenib1