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BCR::ABL1 T315I — resistance to TKIs

Gene: BCR::ABL1 · Type: mutation

Indications: Chronic myeloid leukemia

SensitivityResistanceCIViC Context

Linked CIViC Profile: BCR-ABL T315I

Evidence Level Distribution

Level A: 5Level B: 31Level C: 152Level D: 146
LevelTypeDirectionSignificanceDiseaseDrugsRating
APredictiveSupportsSensitivity/ResponseAcute Myeloid LeukemiaImatinib5
APredictiveSupportsSensitivity/ResponseChronic Myeloid LeukemiaImatinib5
APredictiveSupportsSensitivity/ResponseChronic Myeloid LeukemiaImatinib5
BPredictiveSupportsResistanceChronic Myeloid LeukemiaDasatinib5
BPredictiveSupportsSensitivity/ResponseChronic Myeloid LeukemiaPonatinib5
ADiagnosticSupportsPositiveChronic Myeloid Leukemia4
DPredictiveSupportsResistanceChronic Myeloid LeukemiaImatinib4
BPredictiveSupportsResistanceChronic Myeloid LeukemiaImatinib4
DPredictiveSupportsResistanceChronic Myeloid LeukemiaImatinib4
APredictiveSupportsSensitivity/ResponseChronic Myeloid LeukemiaDasatinib,Nilotinib4
BPredictiveSupportsSensitivity/ResponseChronic Myeloid LeukemiaPonatinib4
CPredictiveSupportsResistanceChronic Myeloid LeukemiaImatinib4
DPredictiveSupportsResistanceChronic Myeloid LeukemiaImatinib4
DPredictiveSupportsResistanceChronic Myeloid LeukemiaImatinib4
DPredictiveSupportsResistanceChronic Myeloid LeukemiaNilotinib4
CPredictiveSupportsResistanceChronic Myeloid LeukemiaImatinib4
CPredictiveDoes Not SupportResistanceChronic Myeloid LeukemiaDasatinib4
CPredictiveSupportsSensitivity/ResponseChronic Myeloid LeukemiaAxitinib4
BPredictiveDoes Not SupportResistanceChronic Myeloid LeukemiaDasatinib4
CPredictiveDoes Not SupportResistanceChronic Myeloid LeukemiaDasatinib4