BRAF non-V600 — resistance to vemurafenib
Gene: BRAF · Type: mutation
Indications: Melanoma
Linked CIViC Profile: BRAF MUTATION
Evidence Level Distribution
Level B: 10Level D: 2
| Level | Type | Direction | Significance | Disease | Drugs | Rating |
|---|---|---|---|---|---|---|
| D | Predictive | Supports | Sensitivity/Response | Cancer | Trametinib | 4 |
| B | Prognostic | Supports | Poor Outcome | Colorectal Cancer | 4 | |
| B | Prognostic | Supports | Poor Outcome | Colorectal Cancer | 4 | |
| B | Predictive | Does Not Support | Sensitivity/Response | Colorectal Cancer | Panitumumab,Cetuximab | 3 |
| B | Predictive | Supports | Resistance | Colorectal Cancer | Cetuximab,Chemotherapy | 3 |
| B | Prognostic | Supports | Poor Outcome | Colorectal Cancer | 3 | |
| B | Predictive | Supports | Resistance | Colorectal Cancer | Oxaliplatin | 3 |
| B | Predictive | Supports | Resistance | Colorectal Cancer | Irinotecan | 3 |
| B | Predictive | Supports | Resistance | Colorectal Cancer | Bevacizumab | 3 |
| B | Predictive | Supports | Resistance | Colorectal Cancer | Cetuximab | 3 |
| B | Prognostic | Supports | Poor Outcome | Colorectal Cancer | 3 | |
| D | Predictive | Supports | Resistance | Colorectal Cancer | Cetuximab | 2 |