CTNNB1 / β-catenin pathway (desmoid tumor)
Gene: CTNNB1 · Type: mutation
Indications: Desmoid tumor
Linked CIViC Profile: CTNNB1 MUTATION
Evidence Level Distribution
Level B: 13Level C: 1Level D: 1
| Level | Type | Direction | Significance | Disease | Drugs | Rating |
|---|---|---|---|---|---|---|
| B | Diagnostic | Supports | Positive | Desmoid Tumor | 4 | |
| B | Diagnostic | Supports | Positive | Desmoid Tumor | 4 | |
| D | Predictive | Supports | Resistance | Melanoma | Anti-CTLA-4 Monoclonal Antibody,Anti-PD-L1 Monoclonal Antibody | 4 |
| B | Diagnostic | Supports | Positive | Desmoid Tumor | 4 | |
| B | Diagnostic | Supports | Positive | Desmoid Tumor | 4 | |
| B | Prognostic | Does Not Support | Poor Outcome | Desmoid Tumor | 4 | |
| B | Diagnostic | Supports | Positive | Childhood Medulloblastoma | 4 | |
| B | Prognostic | Supports | Poor Outcome | Desmoid Tumor | 4 | |
| B | Diagnostic | Supports | Positive | Desmoid Tumor | 3 | |
| B | Prognostic | Supports | Poor Outcome | Desmoid Tumor | 3 | |
| B | Prognostic | Supports | Better Outcome | Desmoid Tumor | 3 | |
| B | Diagnostic | Supports | Positive | Desmoid Tumor | 3 | |
| B | Diagnostic | Supports | Positive | Childhood Medulloblastoma | 3 | |
| C | Predictive | Does Not Support | Sensitivity/Response | Desmoid Tumor | Meloxicam | 2 |
| B | Prognostic | Supports | Better Outcome | Desmoid Tumor | 1 |