DPYD *2A — fluoropyrimidine toxicity
Gene: DPYD · Type: variant
Indications: Solid tumors
Linked CIViC Profile: DPYD MUTATION
Evidence Level Distribution
Level A: 3Level C: 1
| Level | Type | Direction | Significance | Disease | Drugs | Rating |
|---|---|---|---|---|---|---|
| A | Predictive | Supports | Adverse Response | Cancer | Capecitabine,Tegafur,Fluorouracil | 5 |
| A | Predictive | Supports | Adverse Response | Cancer | Fluorouracil,Capecitabine,Tegafur | 5 |
| A | Predictive | Supports | Adverse Response | Cancer | Fluorouracil,Tegafur,Capecitabine | 5 |
| C | Predictive | Supports | Sensitivity/Response | Head And Neck Squamous Cell Carcinoma | Fluorouracil,Leucovorin | 4 |