CIViC Compass
Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.
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HER2 amplification / overexpression

Gene: ERBB2 · Type: amplification

Indications: Breast cancer, Gastric cancer

SensitivityResistanceCIViC Context

FDA Sensitivity Assertions

DrugIndicationRecommendationFDA SourceLink
TrastuzumabBreast cancer, Gastric cancerINDICATED
FDA CDx
Label
PertuzumabBreast cancer, Gastric cancerINDICATED
FDA Label
Label
Ado-trastuzumab emtansineBreast cancer, Gastric cancerINDICATED
FDA Label
Label
Fam-trastuzumab deruxtecanBreast cancer, Gastric cancerINDICATED
FDA Label
Label
TucatinibBreast cancer, Gastric cancerINDICATED
FDA Label
Label
NeratinibBreast cancer, Gastric cancerINDICATED
FDA Label
Label
LapatinibBreast cancer, Gastric cancerINDICATED
FDA Label
Label
MargetuximabBreast cancer, Gastric cancerINDICATED
FDA Label
Label