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Hormone receptor positive (ER+/PR+)

Gene: ESR1 · Type: expression

Indications: Breast cancer

Sensitivity Resistance CIViC Context

Evidence Level Distribution

Level A: 1Level B: 2Level D: 11

Level	Type	Direction	Significance	Disease	Drugs	Rating
D	Predictive	Supports	Sensitivity/Response	Breast Cancer	Tamoxifen,Fulvestrant	5
D	Predictive	Supports	Sensitivity/Response	Breast Cancer	Fulvestrant,Tamoxifen	5
D	Predictive	Supports	Sensitivity/Response	Breast Cancer	Fulvestrant,Tamoxifen	5
D	Predictive	Supports	Sensitivity/Response	Breast Cancer	Tamoxifen,Fulvestrant	5
D	Predictive	Supports	Sensitivity/Response	Breast Cancer	Fulvestrant,Tamoxifen	5
B	Predictive	Supports	Sensitivity/Response	Breast Cancer	Palbociclib,Letrozole	4
A	Predictive	Supports	Sensitivity/Response	Breast Cancer	Elacestrant	4
D	Predictive	Supports	Resistance	Breast Cancer	Hormone Therapy	3
D	Predictive	Supports	Resistance	Breast Cancer	Hormone Therapy	3
D	Predictive	Supports	Resistance	Breast Cancer	Hormone Therapy	3
D	Predictive	Supports	Resistance	Breast Cancer	Hormone Therapy	3
D	Predictive	Supports	Resistance	Breast Cancer	Hormone Therapy	3
D	Predictive	Supports	Resistance	Estrogen-receptor Positive Breast Cancer	Aromatase Inhibitor	2
B	Predictive	Does Not Support	Sensitivity/Response	Breast Cancer	Palbociclib,Letrozole	2