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IDH1 R132 mutation

Gene: IDH1 · Type: mutation

Indications: Acute myeloid leukemia, Cholangiocarcinoma

Sensitivity Resistance CIViC Context

Linked CIViC Profile: IDH1 MUTATION

Evidence Level Distribution

Level A: 1Level B: 3Level C: 1Level D: 1

Level	Type	Direction	Significance	Disease	Drugs	Rating
B	Prognostic	Supports	Better Outcome	Chondrosarcoma		4
B	Prognostic	Supports	Better Outcome	Brain Glioma		3
D	Predictive	Supports	Sensitivity/Response	Brain Glioma	Olaparib	3
A	Predictive	Supports	Sensitivity/Response	Acute Myeloid Leukemia	Ivosidenib	3
B	Predictive	Supports	Sensitivity/Response	Cholangiocarcinoma	Ivosidenib	3
C	Predictive	Supports	Sensitivity/Response	Acute Myeloid Leukemia	Venetoclax	3