IDH1 mutation (cholangiocarcinoma)
Gene: IDH1 · Type: mutation
Indications: Cholangiocarcinoma
Linked CIViC Profile: IDH1 R132
Evidence Level Distribution
Level A: 1Level B: 9Level D: 1
| Level | Type | Direction | Significance | Disease | Drugs | Rating |
|---|---|---|---|---|---|---|
| B | Prognostic | Supports | Better Outcome | Glioblastoma | 5 | |
| B | Prognostic | Supports | Better Outcome | Malignant Astrocytoma | 5 | |
| A | Predictive | Supports | Sensitivity/Response | Cholangiocarcinoma | Ivosidenib | 5 |
| B | Prognostic | Supports | Poor Outcome | Myelodysplastic Syndrome | 4 | |
| D | Predictive | Supports | Sensitivity/Response | Intrahepatic Cholangiocarcinoma | Dasatinib | 4 |
| B | Prognostic | Does Not Support | Acute Myeloid Leukemia | 3 | ||
| B | Prognostic | Supports | Better Outcome | Malignant Astrocytoma | 3 | |
| B | Prognostic | Supports | Better Outcome | Glioblastoma | 3 | |
| B | Diagnostic | Supports | Positive | Acute Myeloid Leukemia | 2 | |
| B | Prognostic | Does Not Support | Acute Myeloid Leukemia | 2 | ||
| B | Predictive | Supports | Sensitivity/Response | High Grade Glioma | Sunitinib,Bevacizumab | 2 |