CIViC Compass
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KIT D816V mutation (systemic mastocytosis)

Gene: KIT · Type: mutation

Indications: Systemic mastocytosis

SensitivityResistanceCIViC Context

Linked CIViC Profile: KIT D816V

Evidence Level Distribution

Level B: 3Level C: 1Level D: 1
LevelTypeDirectionSignificanceDiseaseDrugsRating
BPrognosticSupportsPoor OutcomeAcute Myeloid Leukemia4
BPredictiveSupportsSensitivity/ResponseSystemic MastocytosisMidostaurin4
BPrognosticSupportsPoor OutcomeSystemic Mastocytosis4
DPredictiveSupportsResistanceCancerImatinib2
CPredictiveSupportsResistanceCancerImatinib,Dasatinib2