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NF1 mutation (plexiform neurofibroma)

Gene: NF1 · Type: mutation

Indications: Plexiform neurofibroma

Sensitivity Resistance CIViC Context

Linked CIViC Profile: NF1

Evidence Level Distribution

Level A: 2Level B: 2Level C: 1Level D: 4

Level	Type	Direction	Significance	Disease	Drugs	Rating
C	Predictive	Supports	Resistance	Skin Melanoma	Vemurafenib	4
A	Predictive	Supports	Sensitivity/Response	Plexiform Neurofibroma	Selumetinib	4
D	Predictive	Supports	Sensitivity/Response	Skin Melanoma	Sirolimus,Mirdametinib	3
D	Predictive	Supports	Sensitivity/Response	Malignant Peripheral Nerve Sheath Tumor	JQ1 Compound	3
A	Predictive	Supports	Sensitivity/Response	Plexiform Neurofibroma	Selumetinib	3
B	Predictive	Supports	Sensitivity/Response	Childhood Low-grade Glioma	Selumetinib	3
B	Predictive	Does Not Support	Sensitivity/Response	Cancer	Trametinib	3
D	Predictive	Supports	Resistance	Skin Melanoma	Vemurafenib	2
D	Predictive	Supports	Sensitivity/Response	Skin Melanoma	VTX-11e,AZ628	2