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NRAS any mutation (colorectal)

Gene: NRAS · Type: mutation

Indications: Colorectal cancer

Sensitivity Resistance CIViC Context

Linked CIViC Profile: NRAS MUTATION

Evidence Level Distribution

Level A: 1Level B: 12Level C: 1Level D: 5

Level	Type	Direction	Significance	Disease	Drugs	Rating
B	Predictive	Supports	Sensitivity/Response	Skin Melanoma	Binimetinib	5
B	Prognostic	Supports		Multiple Myeloma		4
D	Predictive	Supports	Sensitivity/Response	Melanoma	Trametinib,Omipalisib	4
A	Predictive	Supports	Resistance	Colorectal Cancer	Cetuximab,Panitumumab	4
B	Prognostic	Supports	Poor Outcome	Colorectal Cancer		3
B	Prognostic	Does Not Support		Acute Myeloid Leukemia		3
B	Prognostic	Supports	Poor Outcome	Melanoma		3
D	Predictive	Supports	Sensitivity/Response	Cancer	Metformin,Trametinib	3
D	Predictive	Supports	Sensitivity/Response	Melanoma	Binimetinib	3
B	Predictive	Supports	Sensitivity/Response	Skin Melanoma	Binimetinib,Ribociclib	3
B	Predictive	Does Not Support	Sensitivity/Response	Solid Tumor	Binimetinib	3
C	Predictive	Does Not Support	Resistance	Melanoma	MEK Inhibitor RO4987655	2
B	Predictive	Supports	Sensitivity/Response	Skin Melanoma	Trametinib,Docetaxel	2
B	Predictive	Does Not Support	Sensitivity/Response	Melanoma	Trametinib	2
B	Predictive	Supports	Sensitivity/Response	Skin Melanoma	Binimetinib	2
D	Predictive	Supports	Resistance	Colorectal Cancer	Cetuximab	2
B	Predictive	Supports	Resistance	Colorectal Cancer	Chemotherapy,Cetuximab	2
B	Predictive	Supports	Resistance	Melanoma	Vemurafenib,Dabrafenib	2
D	Predictive	Supports	Sensitivity/Response	Skin Melanoma	Amuvatinib	1