CIViC Compass
Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.
Home/Biomarker

NRG1 gene fusion

Gene: NRG1 · Type: fusion

Indications: Non-small cell lung cancer, Pancreatic cancer

SensitivityResistanceCIViC Context

Linked CIViC Profile: NRG1 FUSION

Evidence Level Distribution

Level B: 1Level D: 5
LevelTypeDirectionSignificanceDiseaseDrugsRating
DPredictiveSupportsSensitivity/ResponseHead And Neck Squamous Cell CarcinomaLapatinib4
DPredictiveSupportsResistanceColorectal CancerCetuximab4
BPredictiveSupportsSensitivity/ResponseLung Non-small Cell CarcinomaPatritumab4
DPredictiveSupportsSensitivity/ResponseOvarian CancerSeribantumab3
DPredictiveSupportsSensitivity/ResponseLung Non-small Cell CarcinomaCisplatin,Carboplatin,Gemcitabine,Paclitaxel3
DPredictiveSupportsSensitivity/ResponseCancerAnti-ErbB3 Monoclonal Antibody AV-2033