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Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.
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Biomarker
NUDT15 reduced activity — thiopurine toxicity
Gene:
NUDT15
· Type:
variant
Indications: Acute lymphoblastic leukemia
Sensitivity
Resistance
CIViC Context
FDA Resistance Assertions
Drug
Indication
Recommendation
FDA Source
Link
Mercaptopurine
Acute lymphoblastic leukemia
NOT RECOMMENDED
FDA Label
Label
Thioguanine
Acute lymphoblastic leukemia
NOT RECOMMENDED
FDA Label
Label