Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.

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PDGFRA D842V mutation (GIST)

Gene: PDGFRA · Type: mutation

Indications: Gastrointestinal stromal tumor

Sensitivity Resistance CIViC Context

Linked CIViC Profile: PDGFRA D842V

Evidence Level Distribution

Level B: 4Level C: 2Level D: 5

Level	Type	Direction	Significance	Disease	Drugs	Rating
B	Predictive	Supports	Resistance	Gastrointestinal Stromal Tumor	Imatinib	4
B	Predictive	Supports	Resistance	Gastrointestinal Stromal Tumor	Imatinib	4
D	Predictive	Supports	Sensitivity/Response	Gastrointestinal Stromal Tumor	Crenolanib	4
B	Predictive	Supports	Resistance	Gastrointestinal Stromal Tumor	Imatinib	4
B	Diagnostic	Supports	Negative	Gastrointestinal Stromal Tumor		3
D	Predictive	Supports	Resistance	Gastrointestinal Stromal Tumor	Imatinib	3
C	Predictive	Supports	Resistance	Gastrointestinal Stromal Tumor	Sunitinib	3
D	Predictive	Supports	Resistance	Cancer	Imatinib	2
C	Predictive	Supports	Resistance	Gastrointestinal Stromal Tumor	Imatinib	2
D	Predictive	Supports	Resistance	Cancer	Sunitinib	2
D	Predictive	Supports	Resistance	Cancer	Imatinib Mesylate	2