PML::RARA fusion (APL)
Gene: PML::RARA · Type: fusion
Indications: Acute myeloid leukemia
Evidence Level Distribution
Level A: 2Level B: 4Level C: 6
| Level | Type | Direction | Significance | Disease | Drugs | Rating |
|---|---|---|---|---|---|---|
| B | Predictive | Supports | Sensitivity/Response | Acute Promyelocytic Leukemia | Tretinoin | 5 |
| A | Diagnostic | Supports | Positive | Acute Promyelocytic Leukemia | 5 | |
| A | Predictive | Supports | Sensitivity/Response | Acute Promyelocytic Leukemia | Tretinoin,Arsenic Trioxide | 5 |
| C | Predictive | Supports | Resistance | Acute Promyelocytic Leukemia | Tretinoin | 4 |
| B | Predictive | Supports | Resistance | Acute Promyelocytic Leukemia | Arsenic Trioxide | 4 |
| C | Diagnostic | Supports | Positive | Acute Promyelocytic Leukemia With PML-RARA | 4 | |
| C | Diagnostic | Supports | Positive | Acute Promyelocytic Leukemia With PML-RARA | 4 | |
| C | Diagnostic | Supports | Positive | Acute Promyelocytic Leukemia With PML-RARA | 4 | |
| B | Diagnostic | Supports | Positive | Acute Promyelocytic Leukemia With PML-RARA | 4 | |
| B | Diagnostic | Supports | Positive | Acute Promyelocytic Leukemia With PML-RARA | 4 | |
| C | Predictive | Supports | Resistance | Acute Promyelocytic Leukemia | Tretinoin | 3 |
| C | Predictive | Supports | Sensitivity/Response | Acute Promyelocytic Leukemia | Tretinoin | 3 |