PTEN loss / mutation (HR+/HER2- breast)
Gene: PTEN · Type: loss
Indications: Breast cancer
Linked CIViC Profile: PTEN MUTATION
Evidence Level Distribution
Level B: 1Level C: 1Level D: 4
| Level | Type | Direction | Significance | Disease | Drugs | Rating |
|---|---|---|---|---|---|---|
| B | Predictive | Does Not Support | Sensitivity/Response | Endometrial Carcinoma | Everolimus | 3 |
| D | Predictive | Supports | Resistance | Head And Neck Squamous Cell Carcinoma | Taselisib | 3 |
| D | Predictive | Supports | Sensitivity/Response | Cancer | Ipatasertib | 3 |
| D | Predictive | Supports | Sensitivity/Response | Prostate Adenocarcinoma | Alpelisib,PI3Kbeta Inhibitor AZD8186,Enzalutamide | 3 |
| D | Predictive | Does Not Support | Sensitivity/Response | Head And Neck Cancer | Pictilisib,Tanespimycin | 2 |
| C | Diagnostic | Supports | Positive | Glioblastoma | 2 |