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TMB-High (>=10 mut/Mb)

Gene: TMB · Type: tmb

Indications: Solid tumors

Sensitivity Resistance CIViC Context

Linked CIViC Profile: TMB-H

Evidence Level Distribution

Level B: 12

Level	Type	Direction	Significance	Disease	Drugs	Rating
B	Predictive	Supports	Sensitivity/Response	Colorectal Cancer	Durvalumab,Tremelimumab	4
B	Predictive	Supports	Sensitivity/Response	Lung Non-small Cell Carcinoma	Pembrolizumab	4
B	Predictive	Supports	Sensitivity/Response	Solid Tumors, Advanced	Immune Checkpoint Inhibitor	4
B	Predictive	Supports	Sensitivity/Response	Lung Non-small Cell Carcinoma	PD1 Inhibitor,PD-L1 Inhibitor	4
B	Predictive	Supports	Sensitivity/Response	Lung Non-small Cell Carcinoma	Atezolizumab	4
B	Predictive	Supports	Sensitivity/Response	Solid Tumor	Pembrolizumab	4
B	Predictive	Supports	Sensitivity/Response	Lung Adenocarcinoma	Ipilimumab/Nivolumab Regimen	4
B	Predictive	Supports	Sensitivity/Response	Lung Non-small Cell Carcinoma	Immune Checkpoint Inhibitor	4
B	Predictive	Supports	Sensitivity/Response	Lung Non-small Cell Carcinoma	Toripalimab,Chemotherapy	4
B	Predictive	Supports	Sensitivity/Response	Lung Non-small Cell Carcinoma	Ipilimumab/Nivolumab Regimen	3
B	Predictive	Supports	Sensitivity/Response	Lung Non-small Cell Carcinoma	Durvalumab/Tremelimumab Regimen	3
B	Predictive	Supports	Sensitivity/Response	Colorectal Cancer	Pembrolizumab	1