TP53 deletion / del(17p) (chronic lymphocytic leukemia)
Gene: TP53 · Type: deletion
Indications: Chronic lymphocytic leukemia
Linked CIViC Profile: TP53 MUTATION
Evidence Level Distribution
Level A: 1Level B: 22Level C: 2Level D: 2
| Level | Type | Direction | Significance | Disease | Drugs | Rating |
|---|---|---|---|---|---|---|
| B | Prognostic | Supports | Poor Outcome | Chronic Lymphocytic Leukemia | 5 | |
| B | Prognostic | Supports | Poor Outcome | Chronic Lymphocytic Leukemia | 5 | |
| A | Prognostic | Supports | Poor Outcome | Chronic Lymphocytic Leukemia | 5 | |
| B | Prognostic | Supports | Lung Non-small Cell Carcinoma | 5 | ||
| B | Prognostic | Supports | Poor Outcome | Medulloblastoma SHH Activated | 5 | |
| B | Prognostic | Supports | Poor Outcome | Esophagus Squamous Cell Carcinoma | 4 | |
| B | Prognostic | Supports | Poor Outcome | B-lymphoblastic Leukemia/lymphoma | 4 | |
| B | Prognostic | Supports | Poor Outcome | Myelodysplastic Syndrome | 4 | |
| B | Prognostic | Supports | Poor Outcome | Myeloid Neoplasm | 4 | |
| B | Prognostic | Does Not Support | Poor Outcome | Head And Neck Squamous Cell Carcinoma | 4 | |
| B | Prognostic | Supports | Poor Outcome | Head And Neck Squamous Cell Carcinoma | 4 | |
| B | Prognostic | Supports | Poor Outcome | B-lymphoblastic Leukemia/lymphoma | 4 | |
| D | Predictive | Supports | Sensitivity/Response | Breast Cancer | Doxorubicin | 4 |
| B | Prognostic | Supports | Poor Outcome | Acute Myeloid Leukemia | 4 | |
| B | Prognostic | Supports | Poor Outcome | Chronic Lymphocytic Leukemia | 4 | |
| B | Predictive | Supports | Sensitivity/Response | Myelodysplastic Syndrome | Azacitidine,Eprenetapopt | 4 |
| B | Prognostic | Supports | Poor Outcome | Breast Cancer | 3 | |
| B | Prognostic | Does Not Support | Poor Outcome | Head And Neck Squamous Cell Carcinoma | 3 | |
| B | Predictive | Supports | Sensitivity/Response | Gastric Adenocarcinoma | Chemotherapy | 3 |
| D | Predictive | Supports | Sensitivity/Response | Lung Non-small Cell Carcinoma | Selumetinib,Docetaxel | 3 |