CIViC Compass
Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.
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TPMT reduced activity — thiopurine toxicity

Gene: TPMT · Type: variant

Indications: Acute lymphoblastic leukemia

SensitivityResistanceCIViC Context

FDA Resistance Assertions

DrugIndicationRecommendationFDA SourceLink
MercaptopurineAcute lymphoblastic leukemiaNOT RECOMMENDED
FDA Label
Label
ThioguanineAcute lymphoblastic leukemiaNOT RECOMMENDED
FDA Label
Label